Statistical Methods

An inverse probability weighting method for estimating the net benefit in survival analyses in observational studies


Abstract


Recently, in the context of randomized trials, a measure called the net benefit was developed for survival analysis. As this measure does not require the assumption of proportional hazards, it is an attractive new measure of the treatment effect to apply instead of the hazard ratio calculated under this assumption. However, no method for estimating it has been presented in observational studies. Therefore, we describe a simple method to estimate the net benefit adjusted for confounding, using the inverse probability weight. Our method was illustrated using data from an observational study evaluating the disease-free survival in Ewing’s sarcoma patients.




DOI: https://doi.org/10.2427/12993

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EBPH Epidemiology, Biostatistics and Public Health | ISSN 2282-0930

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.